Master i selvmordsforebyggende arbeid

I Am the Master of My Fate

Is angiotensin I-converting enzyme a "master" disease gene?

Clustering of diseases has been appreciated by health insurers and epidemiologists for some time. Co-morbidity suggests shared pathways of disease. It is by now well agreed that common diseases have a strong genetic component. Here we present evidence that the angiotensin I-converting enzyme (ACE) deletion/deletion (D/D) genotype is associated with a large number of common adult diseases, inclu...

How i read cancer imaging studies: the master class series

The generation of a report of findings and a conclusion for an imaging study is a fundamental process in the diagnostic work-up of cancer patients and plays a critical role in treatment decisions. It is therefore important that cancer imaging specialists understand the needs of referring clinicians and can perform this process in a methodical manner. Surprisingly, in contrast to the literature ...

Three faces of the second law. I. Master equation formulation.

We propose a formulation of stochastic thermodynamics for systems subjected to nonequilibrium constraints (i.e. broken detailed balance at steady state) and furthermore driven by external time-dependent forces. A splitting of the second law occurs in this description leading to three second-law-like relations. The general results are illustrated on specific solvable models. The present paper us...

Master sensors of pathogenic RNA - RIG-I like receptors.

Initiating the immune response to invading pathogens, the innate immune system is constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe-associated molecular patterns (MAMPs). Detection of pathogens triggers intracellular defense mechanisms, such as the secretion of cytokines or chemokines to alarm neighboring cells and attract or activate immune cells. The inna...